Christopher ANTOS Associate Professor, ShanghaiTech University
The Antos group researches tissue regeneration. To understand the biology of regeneration, Dr. Antos is interested in answering three fundamental questions:
1. How are cells at the site of injury induced to regenerate lost tissues?
2. How are cells involved in regeneration controlled to produce the correct pattern?
3. What stops regeneration once the appropriate size is reached?These questions are highly relevant to tissue bioengineering and to the stem cell biology of repair or reconstruction of human tissues. The Antos lab uses the zebrafish to answer these questions, because the zebrafish will regenerate many of its organs, including heart and appendages. Therefore, the lab can describe and dissect the cell and molecular mechanisms involved in the fish’s regeneration abilities and relate them to the limits on mammalian regeneration.
Yelin CHEN Researcher, IRCBC, CAS
Mei DING Researcher, IGDB, CAS
Changchun XIAO Professor, Xiamen University
本实验室主要从事microRNA (miRNA), RNA结合蛋白 （RBP）和翻译调控在免疫系统中的功能与机理研究，着眼于阐明它们在淋巴细胞发育，免疫耐受和自身免疫病，免疫应答，抗体反应，抗病毒反应，抗肿瘤反应，淋巴细胞恶性转化，淋巴癌以及白血病发病机理中的功能和作用机理。过去十余年来，取得了一批原创性科研成果，共发表论文30余篇（包括Cell, Science, Nature Immunology, Immunity, J Exp Med, Nature Communications, Genes & Development, EMBO J, Leukemia)，累计引用达6000余次，其中过去五年被引用3500余次(基于Google Scholar).
Hongzhou GU Professor, Fudan University
Pengyu HUANG Assitant Professor, PI, ShanghaiTech University
iGEM ShanghaiTech2017 Student Group, ShanghaiTech University
Jin JIANG Professor, University of Texas
Jun-Yi LEU Research Fellow, IMB, Academia Sinica
Jianquan NI Professor, Tsinghua University
Ting NI Professor, Fudan University
Yan SONG Investigator, Peking University
The main research interest of my laboratory focuses on the understanding of cellular and molecular mechanisms underlying self-renewal, migration and differentiation of normal and cancer stem cells. Stem cells yield promise for regenerative medicine but also pose huge challenges. It remains uncertain how to inhibit stem-cell-derived tumor formation without harming normal stem cells. It is likewise unclear how directional stem cell migration, a critical step in tissue regeneration, is orchestrated. Using newly-established or previously-unexplored stem cell models in Drosophila, we employ a convergence of fly genetics, cell biology, biochemistry and in vivo imaging to investigate a few fundamental questions: 1) How normal stem cells within a specific tissue are maintained and how to distinguish normal from cancer stem cells? 2) During normal development and upon tissue injury, how guidance cues may be converted into physical movement of stem cells in a timely and directional manner? Since the fundamental principles we unravel using the relatively simple Drosophila stem cell models are likely to be conserved in mammals, our studies promise to provide new insights into anti-cancer therapy and regenerative medicine.
Dong WANG Investigator, Tsinghua University
My laboratory (Cancer and Genomics) is trying to understand the mechanisms underlying regulated gene expression and transcriptional programming/reprogramming in cancer cells during tumorigenesis by utilizing combined genomic, epigenomic and chemical genomic approaches. Current research projects in my laboratory include:
(1) Revealing genetic and epigenetic mechanisms underlying transcriptional reprogramming;
(2) Investigating roles of non-coding RNAs in regulated gene expression;
(3) Using chemical genetics approaches to identify small molecules against cancers;
Hongyan WANG Associate Professor, Deputy Director, Duke-NUS
Dr. Wang is a recipient of Singapore National Academy of Science Young Scientist Award (2008) and National Research Foundation (NRF) Research Fellowship (2009). The choice of self-renewal versus differentiation is a fundamental issue in stem cell and cancer biology. Recently, Drosophila melanogaster neural stem cells, larval brain neuroblasts, were emerged as an excellent model for study stem cell self-renewal and tumorigenesis. We are focused on identifying brain tumor suppressors and underlying mechanisms by which they prevent tumor formation in larval brains. Currently, we are interested in addressing the following key questions: What mutations trigger neural stem cells to become cancer stem cells? How asymmetric divisions of neural stem cells are regulated? What are the mechanisms that prevent more mature cells from dedifferentiating back into neural stem cells?
Lai WEI Professor, Sun Yat-sen University
Ping WEI Professor, Peking University
Abstract: CRISPR adaptation requires several specific processes, including selection of protospacer from invaders (plasmid or virus) and subsequent integration of this sequence into the host CRISPR array at the leader sequence end. In the past a few years, we have successfully established the first native Type I CRISPR-Cas system (also first in Archaea domain) that showed efficient adaptation to a purified virus. With this system, we have answered several important and long-standing open questions in the field of CRISPR adaptation, including the adaptation efficiency, integration specificity, and the self vs nonself discrimination mechanisms during the CRISPR adaptation. We showed that primed adaptation is a more favorable route relative to the intractable naïve adaptation, and appeared to be a major pathway of CRISPR adaptation. We also showed that 19 mutated PAMs elicited priming for type I-B, and 4 consensus PAMs functioned for interference, highlighting the plasticity with which the interference machinery can adapt to escape virus, and explaining how self-priming is specifically avoided. In addition, we revealed that the DNA motifs close to the center of the first repeat are important for spacer integration at the leader end. These insights, together with our recently revealed interference mechanisms, have already helped us in developing novel genome editing tools in haloarchaea, and established a basis for further research of the molecular mechanism of CRISPR-Cas systems.
Hua XIANG Researcher, Inst of Microbio, CAS
Prof. Dr. Hua Xiang graduated with his Bachelor's degree in Biology (1991) and Master's degree in Genetics (1994) from Beijing Normal University, later he got his PhD in Biochemistry and Molecular Biology (1997) from Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS&PUMC). He worked as postdoctoral fellow at University of Medicine & Dentistry of New Jersey (UMDNJ, USA) during 1999-2001, and was appointed as a principle investigator from 2001 and full professor from 2004, at Institute of Microbiology, Chinese Academy of Sciences. Dr. Xiang was awarded the National Science Fund for Distinguished Young Scholars by NSFC in 2009. He currently is the director of State Key Laboratory of Microbial Resources, and the director of the Committee of Microbial Genetics of the Genetics Society of China. He also served as associate editor of Journal of Genetics and Genomics, and editorial board member of Applied and Environmental Microbiology, Frontiers in Microbiology and Acta Microbiologica Sinica etc. The research interests of Dr. Xiang’s Lab are haloarchaeal genetics and metabolisms, current research projects include: 1) Genome replication mechanisms of archaea; 2) CRISPR-Cas system and genome editing; 3) Polyhydroxyalkanoates (bioplastics) biosynthesis by halophiles; and 4) Bioremediation in hypersaline environments.
Yu XUE Professor, Huazhong UST
Dr. Yu Xue is a professor at the Department of Biomedical Engineering of College of Life Science and Technology of Huazhong University of Science and Technology.
He received his B.S. in Polymer Materials and Technology in 2002 and B.E. in Computer Science and Technology in 2003 from the University of Science and Technology of China (USTC). He completed his Ph.D. training in Cell Biology and Bioinformatics in USTC (2002-2006). After a short stage as a research assistant (2007.1-2007.7), he was recruited as an associate professor at the Department of Systems Biology of Life Science School of USTC (2007-2009).
Dr. Xue has published extensively on computational studies of post-translational modifications (PTMs), including developing novel GPS (Group-based Prediction System) series algorithms, studying several new PTMs (eg., epigenetic modifications), constructing easy-to-use softwares and databases, and proteome-wide analysis of PTMs substrates, etc. His group is currently combining systems biology, bioinformatics, and molecular & cellular biology approaches to study genetic variations that potentially influence protein modification status.
Dr. Xue is an academic Editor of PLoS ONE, and an associate Editor of BMC Genomics. He is also an active blogger for ScienceNet (In Chinese, http://blog.sciencenet.cn/u/DaCaiNiao) . He is quite active on pushing the communication and collaboration of young bioinformatists in China.
Dr. Xue hope to resolve ALL computational problems for PTMs, but perhaps this aim might not be realized until his retirement. Thus, any collaborations, discussions and communications from all aspects including experimentalists and bioinformatists are warming welcome.
The most favorable word for Dr. Xue is from Steven Wright, an American comedian and writer: "If you're not part of the solution, you're part of the precipitate".
Li YANG Researcher, PICB, CAS
Yang YANG Assistant Professor, PI, ShanghaiTech University
Dr. Yang Yang graduated from Zhejiang University in 2005 majoring Biomedical engineering, and obtained her PhD degree in Neuroscience from Stony Brook University in 2010. She conducted her thesis work in Dr. Anthony M. Zador’s lab in Cold Spring Harbor Laboratory. She then joined Dr. Mu-ming Poo’s lab in 2011 as a postdoctoral fellow, and became Associate Investigator in 2015. She joined ShanghaiTech in June, 2017 as assistant professor and principle investigator.
Wenqiang YU Professor, Fudan University
Chief-scientist of 973 project “Chromatin decode and its application in medical science”. Professor of “Chang Jiang scholars program”. PI of Institutes of Biomedical sciences of Fudan University. MD and PhD degree from the Fourth Military medical University. From 2001 to 2007 postdoc at Uppsala University and Johns Hopkins University Medical Center focus on epigenetics. From Nov 2007, faculty working in Columbia University as Associate Research Scientist studying on epigenetics and kidney development. Papers are published on Nature, Nature genetics, JAMA.
Yongchun YU Professor, Fudan University
Suwen ZHAO Assistant Professor, PI, ShanghaiTech University
Predicting the full-length structures of multi-domain GPCRs
Discovering ligands for GPCRs and other proteins in cell signaling pathways
Jingqiu ZHOU Researcher, SIBCB, CAS
Min ZHUANG Assistant Professor, PI, ShanghaiTech University
Dr. Min Zhuang graduated from the Department for Intensive Instruction (current name: Kuang Yaming Honors School), Nanjing University in 2003. She completed the graduate training at St Jude Children’s Research Hospital and obtained her Ph.D. degree from The University of Tennessee Health Science Center in 2009. She continued her postdoctoral training in the Department of Pharmaceutical Chemistry at University of California San Francisco. In 2014, she joined ShanghaiTech University as a tenure-track assistant professor, PI in the School of Life Sciences and Technology.
Jie YIN Professor, Vice President & Provost, ShanghaiTech University
Prof. Jie Yin was a professor in Chemistry at Shanghai Jiao Tong University, and served as the Vice President of Shanghai Jiao Tong University for education programs from 2004 to 2009. Currently he is Vice President and Provost of ShanghaiTech University.
Ji-Long LIU Professor, Vice Dean, ShanghaiTech University
Professor Ji-Long Liu obtained a Bachelor degree from Beijing Forestry University in 1992, a Master degree from China Agricultural University in 1995 and a Ph.D. degree from Chinese Academy of Sciences Institute of Zoology in 2000. He was a postdoctoral fellow at the University of Connecticut from July 2000 to December 2002 and at Carnegie Institution for Science Department of Embryology from January 2003 to August 2007. He set up his laboratory and held a Medical Research Council (MRC) Programme Leader-track position at the University of Oxford in August 2007. He was promoted as a Tenured MRC Programme Leader at the University of Oxford in January 2012 (Tenured Programme Leader is the highest academic position in the UK MRC system). In June 2016, Professor Liu joined the School of Life Science and Technology at ShanghaiTech University as a Tenured Full Professor.Pro. Liu is appointed as Vice Dean in April 2017.